Regardless of selected treatment options for cancer, pet parents and veterinary healthcare team members share a common goal – to ensure the best quality of life possible for the pet. Nutrition provides a unique opportunity for pet parents to exert some control over their pet’s condition, and most are open to trying a new food after a diagnosis of cancer. Although most pet parents will search online for nutrition information, they still trust their veterinary healthcare team’s advice and want your guidance. The challenge is knowing what food to recommend and how to manage the ups and downs of appetite that can occur during the course of treatment or disease progression. This presentation highlights the nutritional features desired for pets with cancer and includes practical tips for communicating with pet parents and establishing a nutritional protocol that supports the pet’s quality of life.